
Delphine Larivière developed and maintained bioinformatics workflows in the galaxyproject/iwc repository, focusing on genome assembly, scaffolding, and quality control pipelines. She engineered robust data processing and validation routines using Python and YAML, integrating tools like Compleasm and Mash for assembly reporting and k-mer profiling. Her work emphasized reproducibility and maintainability by removing runtime parameters, standardizing configuration, and expanding automated test coverage. Delphine improved reporting clarity and data integrity through enhanced documentation, workflow annotations, and QC metrics. By streamlining workflow execution and addressing edge-case failures, she enabled more reliable, scalable analyses for genomics researchers using the Galaxy platform.

October 2025: Delivered improvements across galaxyproject/iwc and galaxyproject/tools-iuc that strengthen reporting, QC, and pipeline robustness. Replaced BUSCO with Compleasm reporting in the VGP assembly workflow, with updated tests and workflow configuration, and enhanced assembly statistics reporting. Added Mash QC to the k-mer profiling workflow for PacBio HiFi reads, including heatmap distance visualizations and updated docs. Fixed robustness for absence of middle adaptors in the assembly decontamination workflow, with a new test and config changes. Fixed paired data processing and unsafe character handling in Mash sketch tool, with added test data. Impact: more accurate, actionable assembly reports; improved QC visibility; fewer edge-case failures; better data integrity. Skills demonstrated: workflow configuration, test-driven development, data quality metrics, visualization integration, data sanitization, and cross-repo collaboration.
October 2025: Delivered improvements across galaxyproject/iwc and galaxyproject/tools-iuc that strengthen reporting, QC, and pipeline robustness. Replaced BUSCO with Compleasm reporting in the VGP assembly workflow, with updated tests and workflow configuration, and enhanced assembly statistics reporting. Added Mash QC to the k-mer profiling workflow for PacBio HiFi reads, including heatmap distance visualizations and updated docs. Fixed robustness for absence of middle adaptors in the assembly decontamination workflow, with a new test and config changes. Fixed paired data processing and unsafe character handling in Mash sketch tool, with added test data. Impact: more accurate, actionable assembly reports; improved QC visibility; fewer edge-case failures; better data integrity. Skills demonstrated: workflow configuration, test-driven development, data quality metrics, visualization integration, data sanitization, and cross-repo collaboration.
2025-09 Monthly Summary (galaxyproject/iwc and galaxyproject/tools-iuc) Key features delivered, major fixes, impact, and skills demonstrated across two repositories, focused on reliability, performance, and business value: Key features delivered - VGP-assembly-v2 workflow: enhanced reporting and parameterization (added assembly name, assembly ID, haplotype in reports); improved markdown reports; updated CHANGELOG and README to reflect changes. - VGP assembly workflow QC optimization: refactored QC steps to remove BUSCO and moved alignment/duplication statistics earlier, enabling faster, data-driven QC decisions using raw data. - Runtime-parameter removal across VGP-assembly-v2 and related workflows: eliminated runtime inputs to simplify execution and reduce configuration errors (affecting Assembly-Hifi-Trio-phasing-VGP5). - Scaffolding-HiC-VGP8: 3.0 release with improvements (removal of duplicated Hi-C reads, added duplication statistics, improved reporting; test-file adjustments) and separate runtime-parameter removal for Scaffolding-HiC-VGP8. - ncbi_fcs_gx and related tooling: updated tool version and tests; maintained compatibility and improved IDs handling. - Tooling and data enhancements in tools-iuc: Mash paste integration with metadata/test data; Yahs input support for qname-sorted BAM; Compleasm summary file output; robust file handling using identifiers; linting/dependency updates and test adjustments. Major bugs fixed - Pairtools: fix statistics output bug to ensure correct display of stats. - Fix downstream bug due to typo to resolve downstream issues. Overall impact and accomplishments - Increased pipeline reliability and reproducibility by removing runtime parameters and simplifying execution paths, reducing configuration errors and supporting easier maintenance. - Accelerated QC and reporting workflows, enabling faster decision-making and higher data quality assurance across projects. - Expanded the tool ecosystem (Mash paste, Yahs, Compleasm) with better data handling and testing, improving end-to-end data processing and traceability. - Strengthened code quality and maintainability through linting fixes, dependency updates, and robust file identification strategies. Technologies/skills demonstrated - Python-based workflow modularization and parameterization, version-controlled with clear commit history. - QC data engineering: reorganized statistics flow, early diagnostics, and report generation. - Tooling integration and testing: updates to tests, test data management, and metadata accuracy. - Robust data handling: identifier-based file handling for reliability across variations. - DevOps hygiene: linting, dependency management, CI considerations, and documentation updates.
2025-09 Monthly Summary (galaxyproject/iwc and galaxyproject/tools-iuc) Key features delivered, major fixes, impact, and skills demonstrated across two repositories, focused on reliability, performance, and business value: Key features delivered - VGP-assembly-v2 workflow: enhanced reporting and parameterization (added assembly name, assembly ID, haplotype in reports); improved markdown reports; updated CHANGELOG and README to reflect changes. - VGP assembly workflow QC optimization: refactored QC steps to remove BUSCO and moved alignment/duplication statistics earlier, enabling faster, data-driven QC decisions using raw data. - Runtime-parameter removal across VGP-assembly-v2 and related workflows: eliminated runtime inputs to simplify execution and reduce configuration errors (affecting Assembly-Hifi-Trio-phasing-VGP5). - Scaffolding-HiC-VGP8: 3.0 release with improvements (removal of duplicated Hi-C reads, added duplication statistics, improved reporting; test-file adjustments) and separate runtime-parameter removal for Scaffolding-HiC-VGP8. - ncbi_fcs_gx and related tooling: updated tool version and tests; maintained compatibility and improved IDs handling. - Tooling and data enhancements in tools-iuc: Mash paste integration with metadata/test data; Yahs input support for qname-sorted BAM; Compleasm summary file output; robust file handling using identifiers; linting/dependency updates and test adjustments. Major bugs fixed - Pairtools: fix statistics output bug to ensure correct display of stats. - Fix downstream bug due to typo to resolve downstream issues. Overall impact and accomplishments - Increased pipeline reliability and reproducibility by removing runtime parameters and simplifying execution paths, reducing configuration errors and supporting easier maintenance. - Accelerated QC and reporting workflows, enabling faster decision-making and higher data quality assurance across projects. - Expanded the tool ecosystem (Mash paste, Yahs, Compleasm) with better data handling and testing, improving end-to-end data processing and traceability. - Strengthened code quality and maintainability through linting fixes, dependency updates, and robust file identification strategies. Technologies/skills demonstrated - Python-based workflow modularization and parameterization, version-controlled with clear commit history. - QC data engineering: reorganized statistics flow, early diagnostics, and report generation. - Tooling integration and testing: updates to tests, test data management, and metadata accuracy. - Robust data handling: identifier-based file handling for reliability across variations. - DevOps hygiene: linting, dependency management, CI considerations, and documentation updates.
August 2025: Delivered major enhancements and cleanup across the galaxyproject/iwc workflows, focusing on robustness, standardization, and reliability. Key PRs implemented features for Hi-C scaffolding with single-element collections, standardized the Genetic Code parameter across mitogenome/MitoHiFi workflows, and migrated decontamination to the NCBI FCS-GX suite. Simultaneously simplified configuration by removing runtime inputs, and fixed critical test data and extraction issues to improve test reliability and reporting. The changes collectively reduce runtime risk, improve reproducibility, and accelerate pipeline execution for end users.
August 2025: Delivered major enhancements and cleanup across the galaxyproject/iwc workflows, focusing on robustness, standardization, and reliability. Key PRs implemented features for Hi-C scaffolding with single-element collections, standardized the Genetic Code parameter across mitogenome/MitoHiFi workflows, and migrated decontamination to the NCBI FCS-GX suite. Simultaneously simplified configuration by removing runtime inputs, and fixed critical test data and extraction issues to improve test reliability and reporting. The changes collectively reduce runtime risk, improve reproducibility, and accelerate pipeline execution for end users.
July 2025 monthly summary for galaxyproject tools-iuc and iwc focusing on delivering business value through robust test data accuracy, streamlined workflows, and enhanced QC reporting. Key improvements reduced configuration complexity, improved test reliability, and expanded QC visibility for alternate assemblies across two repos.
July 2025 monthly summary for galaxyproject tools-iuc and iwc focusing on delivering business value through robust test data accuracy, streamlined workflows, and enhanced QC reporting. Key improvements reduced configuration complexity, improved test reliability, and expanded QC visibility for alternate assemblies across two repos.
June 2025 performance summary for galaxyproject/iwc: Delivered a focused set of stability, data-processing, and test-coverage improvements. Key features include MAPQ filtering with outputs for both filtered and unfiltered maps, and merged assembly stats output, complemented by changelog updates. Major bug fixes addressed a compleasm issue and an indentation problem, while configuration clarity was improved by removing runtime parameters and enforcing default values for non-optional inputs. Overall, this month strengthened reliability, data quality, and maintainability, enabling safer deployments and clearer downstream analyses.
June 2025 performance summary for galaxyproject/iwc: Delivered a focused set of stability, data-processing, and test-coverage improvements. Key features include MAPQ filtering with outputs for both filtered and unfiltered maps, and merged assembly stats output, complemented by changelog updates. Major bug fixes addressed a compleasm issue and an indentation problem, while configuration clarity was improved by removing runtime parameters and enforcing default values for non-optional inputs. Overall, this month strengthened reliability, data quality, and maintainability, enabling safer deployments and clearer downstream analyses.
May 2025 monthly summary for galaxyproject/iwc: Focused on streamlining configuration, stabilizing core tooling, expanding analytics capabilities, and strengthening test/documentation to enable reliable releases.
May 2025 monthly summary for galaxyproject/iwc: Focused on streamlining configuration, stabilizing core tooling, expanding analytics capabilities, and strengthening test/documentation to enable reliable releases.
April 2025 performance highlights for galaxyproject/iwc. Key features and improvements improved alignment control and reporting, enhanced workflow reliability, and broadened VGP annotations and documentation. Consolidated release hygiene with updated CHANGELOG and tests, coupled with targeted UI and plotting workflow improvements. The work delivered: - BWA-MEM enhancements: added -5 option; removed -a; tuned parameters; produced BUSCO GFF for downstream analysis (commits: 0450ffe, 4669acd, 2bb05037). - Replacement of alignment merging tools to improve workflow reliability (commit: d9ca5c7289ced6bfe96f24d704c4f26247805b4e). - VGP annotations and documentation across VGP0–VGP9, including updated READMEs (multiple commits). - UI and plotting workflow improvements: changed box title; refined plotting workflow annotation and README (commits: 351748219cbd484741c75d20b0ee3d5a34f93661, 00d60ded2cef633c6925f58301e54e398914b9f9, e78a982b8e3c40050dba654febbdd7f554b44ee2). - Release hygiene and quality: added workflow report; updated CHANGELOG; fixed typos in VGP3 and version number; added BUSCO for hap2; housekeeping commits (006cb128, c0998f5c8c839961a927698a45429b46524882e0, eab8685f2646d6b91d5b8cbab773a7956d13a0a0, 540f2ff04d17ef70c421c885f3d999f71a676b66, 00e8eb00607ccd1934525fa8045f19abbf7ba17d).
April 2025 performance highlights for galaxyproject/iwc. Key features and improvements improved alignment control and reporting, enhanced workflow reliability, and broadened VGP annotations and documentation. Consolidated release hygiene with updated CHANGELOG and tests, coupled with targeted UI and plotting workflow improvements. The work delivered: - BWA-MEM enhancements: added -5 option; removed -a; tuned parameters; produced BUSCO GFF for downstream analysis (commits: 0450ffe, 4669acd, 2bb05037). - Replacement of alignment merging tools to improve workflow reliability (commit: d9ca5c7289ced6bfe96f24d704c4f26247805b4e). - VGP annotations and documentation across VGP0–VGP9, including updated READMEs (multiple commits). - UI and plotting workflow improvements: changed box title; refined plotting workflow annotation and README (commits: 351748219cbd484741c75d20b0ee3d5a34f93661, 00d60ded2cef633c6925f58301e54e398914b9f9, e78a982b8e3c40050dba654febbdd7f554b44ee2). - Release hygiene and quality: added workflow report; updated CHANGELOG; fixed typos in VGP3 and version number; added BUSCO for hap2; housekeeping commits (006cb128, c0998f5c8c839961a927698a45429b46524882e0, eab8685f2646d6b91d5b8cbab773a7956d13a0a0, 540f2ff04d17ef70c421c885f3d999f71a676b66, 00e8eb00607ccd1934525fa8045f19abbf7ba17d).
In March 2025, the IW-C project delivered notable Hi-C workflow improvements in galaxyproject/iwc, focusing on performance, reliability, and clarity. Key deliverables include: 1) Hi-C Scaffolding workflow simplifications that remove unnecessary sorting and streamline tool state for faster, more reliable runs; 2) Hi-C Contact Map workflow enhancements by replacing Picard MergeSamFiles with a samtools-based merge, updating BWA-MEM2, and refining configuration/outputs for higher-quality maps; 3) Documentation and workflow naming consistency with README updates and beta-tag annotations to improve discoverability; 4) Beta release tagging and changelog updates reflecting 1.0beta1 status; 5) Deterministic runtime for the VGP-assembly-v2 workflow by removing runtime parameters to simplify execution and increase reproducibility. These changes collectively improve throughput, output consistency, and maintainability while signaling a clear beta deployment path for future validation and iteration.
In March 2025, the IW-C project delivered notable Hi-C workflow improvements in galaxyproject/iwc, focusing on performance, reliability, and clarity. Key deliverables include: 1) Hi-C Scaffolding workflow simplifications that remove unnecessary sorting and streamline tool state for faster, more reliable runs; 2) Hi-C Contact Map workflow enhancements by replacing Picard MergeSamFiles with a samtools-based merge, updating BWA-MEM2, and refining configuration/outputs for higher-quality maps; 3) Documentation and workflow naming consistency with README updates and beta-tag annotations to improve discoverability; 4) Beta release tagging and changelog updates reflecting 1.0beta1 status; 5) Deterministic runtime for the VGP-assembly-v2 workflow by removing runtime parameters to simplify execution and increase reproducibility. These changes collectively improve throughput, output consistency, and maintainability while signaling a clear beta deployment path for future validation and iteration.
February 2025 monthly summary for galaxyproject/iwc: Delivered a mix of refactoring, test improvements, and CI/config enhancements that stabilize runtime behavior, accelerate validation, and improve maintainability. Key business value includes reduced configuration issues, faster feedback loops, and clearer deployment pipelines, enabling more reliable data processing workflows.
February 2025 monthly summary for galaxyproject/iwc: Delivered a mix of refactoring, test improvements, and CI/config enhancements that stabilize runtime behavior, accelerate validation, and improve maintainability. Key business value includes reduced configuration issues, faster feedback loops, and clearer deployment pipelines, enabling more reliable data processing workflows.
January 2025 monthly summary for galaxyproject/iwc focusing on feature delivery, quality improvements, and workflow usability enhancements. Delivered key input validation and annotation enhancements across assembly-related workflows, upgraded BUSCO detection to metaeuk with richer annotations, and improved Scaffolding-HiC-VGP8 usability through descriptive input parameters. These efforts collectively strengthen data integrity, reduce user-entry errors, and improve pipeline configurability and reproducibility for large-scale genome assembly and scaffolding tasks.
January 2025 monthly summary for galaxyproject/iwc focusing on feature delivery, quality improvements, and workflow usability enhancements. Delivered key input validation and annotation enhancements across assembly-related workflows, upgraded BUSCO detection to metaeuk with richer annotations, and improved Scaffolding-HiC-VGP8 usability through descriptive input parameters. These efforts collectively strengthen data integrity, reduce user-entry errors, and improve pipeline configurability and reproducibility for large-scale genome assembly and scaffolding tasks.
December 2024 monthly summary for galaxyproject/iwc. Focused on delivering a robust Busco integration, pipeline stability, and alignment with current tooling. Key outcomes include expanded test coverage, improved output fidelity, and maintainability improvements that reduce onboarding time and increase run reliability.
December 2024 monthly summary for galaxyproject/iwc. Focused on delivering a robust Busco integration, pipeline stability, and alignment with current tooling. Key outcomes include expanded test coverage, improved output fidelity, and maintainability improvements that reduce onboarding time and increase run reliability.
November 2024 performance summary: Delivered documentation and metadata enhancements, codebase reorganization, and workflow integration improvements across galaxyproject/iwc and galaxyproject/galaxy-hub. Key outcomes include metadata enhancements and clearer HiC reads in collections; folder refactoring for maintainability; JBrowse2 output exposure for workflow integration; testing enhancements and test data size reductions for faster feedback; GTA content improvements and editorial fixes. These changes improve onboarding, reproducibility, CI efficiency, and interoperability with common Galaxy workflows.
November 2024 performance summary: Delivered documentation and metadata enhancements, codebase reorganization, and workflow integration improvements across galaxyproject/iwc and galaxyproject/galaxy-hub. Key outcomes include metadata enhancements and clearer HiC reads in collections; folder refactoring for maintainability; JBrowse2 output exposure for workflow integration; testing enhancements and test data size reductions for faster feedback; GTA content improvements and editorial fixes. These changes improve onboarding, reproducibility, CI efficiency, and interoperability with common Galaxy workflows.
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