Alexy Pellegrini contributed to the InsightSoftwareConsortium/ITK repository by improving the build and wrapping pipeline, focusing on stabilizing Python integration and reducing build failures. He addressed wrapping build conflicts by separating per-module .castxml.inc generation, which prevented file overwrites and rebuild issues. Using CMake and C++, Alexy enabled Python wrapping for the ITKVtkGlue module with compatibility for VTK 7.0 and above, updating the build system to locate necessary VTK libraries and provide safeguards for older versions. His work enhanced maintainability and reliability of the wrapping backend, demonstrating a thoughtful approach to build system configuration and cross-language integration.