
Developed an end-to-end scGen perturbation analysis workflow for LPS-stimulation across cell types in the BiodataAnalysisGroup/BioHackathon repository, focusing on single-cell RNA-seq analysis. The work encompassed data preprocessing, model training, prediction of stimulated cell states, and evaluation using metrics and visualizations. Implemented configurable data processing improvements, including PCA dimension constraints and log1p transformation options, leveraging Python, Jupyter Notebook, and libraries such as Scanpy and Pandas. Enhanced the evaluation framework with additional metrics and plots to assess prediction accuracy. Also addressed repository hygiene by refining ignore rules to prevent accidental artifact tracking, ensuring cleaner version control and project maintenance.
Concise monthly summary for 2024-11 focused on delivering an end-to-end scGen perturbation analysis workflow for LPS-stimulation in BioHackathon, plus repository hygiene improvements. Highlights include end-to-end pipeline (preprocessing, model training, predictions of stimulated cell states, evaluation with metrics and visualizations) across existing cell types; targeted improvements for dimensionality handling and data transformation options; and a configuration maintenance effort to tighten ignore rules and prevent accidental artifact tracking.
Concise monthly summary for 2024-11 focused on delivering an end-to-end scGen perturbation analysis workflow for LPS-stimulation in BioHackathon, plus repository hygiene improvements. Highlights include end-to-end pipeline (preprocessing, model training, predictions of stimulated cell states, evaluation with metrics and visualizations) across existing cell types; targeted improvements for dimensionality handling and data transformation options; and a configuration maintenance effort to tighten ignore rules and prevent accidental artifact tracking.

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